Struggling with the Elephant in the Room

A Manic Depressive Blog

Manic Depressive Illness- Will Seroquel be the Death of Me? (Horrible Side-Effects, but Positive Outcome)

Today’s post is an examination of my relationship with Seroquel (it’s a follow up/sequel to my last post). About six months after I was diagnosed with manic depressive illness, my new psychiatrist decided it was time to put me on a “miracle d\rug.” He was convinced that this particular medication was a cure-all for most mental disorders. In fact, he had a backroom filled with samples- he later told me that AstraZeneca would take him out to lunch once a month and provide him with an infinite amount of Seroquel samples.

It was my first visit to the new psychiatrist (My previous psychiatrist was horrible, he treated me like shit and he constantly put me on different meds to see how I would react, I felt like a lab rat) and I was nervous. The receptionist greeted me, took my credit card and told me to take a seat in the lobby. The office was a refurbished house- it was comfortable, with leather chairs and oil paintings hanging on the walls. This was not a typical doctor’s office. A few minutes later, a tall elderly man walked through the front door. He looked in pain; his neck was covered in a brace and hands were shaking. I thought he was another patient. Instead of sitting down in the lobby, he unlocked an office door, walked and slammed it shut. It was all very confusing…

…To save you from the boring details of my first psych visit, I’m going to fast forward a bit:

(http://www.real-selfhelp.org)

We talked for almost an hour, with Dr. M making various comments and observations about my life story. Unlike my previous psych, who prescribed me a med cocktail within the first five minutes of our session, Dr. M genuinely cared about my mental health. When it came time to change my meds, I was confident in Dr. M’s ability as a psych. At that time I was only taking 150mg of Zoloft, unfortunately I was extremely paranoid (I would later find out that one of the side-effects of Zoloft is increased mania and paranoia). Instead of taking me off Zoloft, D.r M decided to add a new drug: Tegretol. The sole purpose of the Tegretol was to combat the Zoloft created paranoia. We ended our session…

The next few days were hell. Although the paranoia decreased, I was unable to sleep and I had this feeling that a depressive episode was about to begin. I was scared. I called Dr. M’s office and demanded that I get an appointment.

At 1pm the next day, I found myself back in Dr. M’s office. He asked me how I was doing and I started to fall apart- I was frustrated, depressed, manic and scared (I suffer from mixed episodes). But more importantly I was vulnerable. Dr. M started telling me about this miracle drug that most of patients were on. It was called Seroquel. There was a caveat- patients who took Seroquel had the potential to develop various side-effects (according to Dr. M, Seroquel had not been on the market long enough to determine its side-effects. He furthered this by stated that  it might be a few decades before we know the total impact Seroquel has on a patient’s life).

I was so desperate to improve my mental health, that I agreed to start taking Seroquel. Dr. M provided me with a brown bag of samples and instructed me to take 50mg each night before I go to bed. At first, I didn’t feel different. However, as the week progressed, the mania and the depression began to dissipate. In fact, I started enjoying life again. Dr. M was right.

A few weeks past and my mental health continued to improve. The only downside was that my weight started to increase…another month went by and I started to get depressed again. What was happening, I thought everything was finally working out? Oh man, I really don’t want to be depressed, I hate being depressed. Why does life have to fuck me over sometimes?  I made a new appointment with Dr. M. Instead of taking me off Seroquel, Dr. M increased my dosage to 100mg…

Present Day:

I’m currently taking 900mg of Seroquel a night (when I was first put on Seroquel, Dr. M explained that dosage limit for Seroquel was around 1400mg. I’m really scared that one day I will be at that dosage level). It still is an amazing drug, as it’s the only thing keeping my mind stable. However, I’ve gained almost 70 pounds since starting Seroquel. On top of that I have a high risk of developing Tardive Dyskinesia, Diabetes as well as other unknown side-effects.

The question is why am I  still taking Seroquel? Why would I willingly take a drug that has so many horrible side-effects? Because it’s the only thing keeping me sane at the moment. Although I still have manic/depressive episodes, they are not as severe as they were 3 years ago. I’m also able to sleep, as my thoughts have stopped racing.

You might think I’m crazy to do this; however, I want to try and enjoy my life…

I hope everyone is having a great Monday Evening.

Stay Strong.

Dave.

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9 thoughts on “Manic Depressive Illness- Will Seroquel be the Death of Me? (Horrible Side-Effects, but Positive Outcome)

  1. Hi Dave. I don’t think you’re crazy. Well, no crazier than anyone else, at any rate.

    You’re trying to be happy. That’s not so much crazy as human.

    I feel for you. I really do. I have gained a lot of weight on antipsychotics and mostly consider them the devil. However, they work for many people and sometimes you have to dance with the devil. That’s just imperfect life for you.

    Regarding drug choice and dosage, all I can say is make the best decision for you. Don’t fix what isn’t broken. You might not like the fix so much. Seroquel is a “wonder” drug for others too.

    I just want to say two things and please know that I am not in any way disagreeing with your approach.

    First, I thought you might like to know Seroquel hasn’t been studied in doses of more than 800mg/day http://www.rxlist.com/seroquel-xr-drug.htm
    Don’t get me wrong, people undoubtedly take it, but the maker is saying it hasn’t been studied. (Don’t freak out. Doctors handle these things differently.)

    And second, I’m guessing you know this, but there are other antipsychotics that are similar to Seroquel that you can try if you ever decide to. I only mention this because you should understand that it’s not Seroquel-or-nothing. It might be reassuring to know you have options, even if you decide to never use them. (Other antipsychotics have slightly different side effect profiles, or you might react differently to them.)

    [Oh, and you probably got this bit from personal experience, but people with bipolar disorder shouldn’t be on antidepressants without mood stabilizers. Some doctors think bipolars shouldn’t take antidepressants at all. http://www.psycheducation.org/bipolar/controversy.htm%5D

    I don’t know if that was helpful, but I think knowledge is power and knowledge dispels fear. So I like to spread that sort of stuff around.

    - Natasha Tracy
    (Not a medical professional. Always talk to your doctor.)

  2. Dave,
    I do not think you’re crazy for continuing it. We have to choose our demons when we are so lucky to be able to. You must do the least destructive, least painful thing for you right now until there is something else. I would urge you, however, to read (if you haven’t already) Carlat’s book Unhinged: the Trouble with Psychiatry…
    I’m sure the info is not too much news for you but it is interesting and sad. I am glad you are feeling some relief. But I have to say this…you don’t ever HAVE to get to that high dose. You do have some say in the matter. It’s just a matter of what you’re wiling to put up with. Good luck.
    Meredith

  3. Natasha Tracy on said:

    I’m terribly suspicious of any book that claims to “expose” anything. I know sensationalistic language and I’m not a huge fan, especially from a doctor.

    Anywho, another (biased) doctor’s critique of the book makes some very fair points I think.

    http://psychiatrist-blog.blogspot.com/2010/05/unhinged-trouble-with-psychiatry-by.html

    But as I writer I understand, you don’t get published without something “shocking” to say.

    - Natasha Tracy
    http://psychiatrist-blog.blogspot.com/2010/05/unhinged-trouble-with-psychiatry-by.html

  4. Michelle on said:

    Thanks for your post. I had similar struggles with Zoloft and went on seroquel. It has not only taken the edge off my most severe symptoms (intense lows and suicidal thoughts), I have finally managed to enjoy sustained mental and emotional stability. The depression isn’t gone completely but it is short-lived and mug easier o cope with.

  5. Using drugs to help keep you stable is nothing to be ashamed of. I know some people do not like meds, and if that works for them, great. But if meds help you that is all that matters.

    Take care,
    Jess

  6. Dave,
    Seroquel is working for me if i exercise, don’t get over loaded, journal, take care of myself, say no, love myself, attend my weekly small group of Christian women, force myself to be active, sleep when necessary, cry if needed and take Zoloft,
    Good luck,
    Pam

  7. NiroZ on said:

    Heh, I tried a whole cocktail of anti-psychotics and anti-depressants. Wasn’t till I found a doctor brave enough to prescribe me lithium that I got better.

  8. Holy crap that is a high dosage. Do you have any hangover in the morning?I find this med takes the edge off of things for me as well.

  9. Well, call me the pessimist, but soon enough you will develop those terrible and potentially permanent problems like tardive dyskenisia and by then the drug would have surely stopped working. As with any drug induced pleasure, doom is looming. The pleasant effects wont last, eventually no drug or combination of drugs will help you, and by then you will be tormented by a plethora of drug induced health problems that you will be then left to suffer with your mental illness worse than ever. At least that’s where I’m at. Just two years ago I was so drugged up that I couldn’t talk. Seriously, I was mute. 13 years ago I began on paxil for depression, within a couple years of that I was on a cocktail of drugs, a few years after that I was in a state mental hospital being forced to take three neuroleptic drugs at once – haldol, prolixin (depot) & risperdal – and I literally couldn’t talk, could barely swallow. I had no thoughts, no feelings. I had to be discharged to a nursing home that thankfully my family removed me from, probably illegally (we’re still sorting it out).

    Now that I’ve withdrawn from all the drugs, I have soooo many problems. I have a moderate-to-severe form of TD that affects not only my jaw but my neck and diaphram (breathing) muscles, and I have dystonic episodes as well. I get terrible feelings of vertigo when thinking, like now, and I writhe around and pull muscles in my sleep. My new pdoc has told me this is permanent and has put me on antiparkinson drugs that have done absolutely nothing, and told me to take 100mg of benadryl 4 times a day, which helps a bit.

    I am what will happen to everybody who keeps taking these drugs eventually. Some people get here after only a couple years, others may take 20, but eventually everyone winds up with these problems when they take those drugs so you can bet on it. Your future will be miserable.

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